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Related Experiment Video

Updated: Mar 14, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Axillary lymph node micrometastases decrease triple-negative early breast cancer survival.

G Houvenaeghel1, R Sabatier1, F Reyal2

  • 1Institut Paoli Calmettes and Centre de Recherche en Cancérologie de Marseille, INSERM U1068, CNRS U7258, 232 Bd Ste Marguerite, Marseille, France.

British Journal of Cancer
|September 30, 2016
PubMed
Summary
This summary is machine-generated.

Axillary lymph node involvement (ALNI) significantly impacts survival in early triple-negative breast cancer (TNBC). Even small amounts of cancer cells in lymph nodes are a key prognostic factor, regardless of chemotherapy.

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Area of Science:

  • Oncology
  • Breast Cancer Research
  • Cancer Prognostics

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive subtype with unclear prognostic markers.
  • The prognostic significance of axillary lymph node involvement (ALNI) in TNBC requires further elucidation.
  • Focus on small axillary metastases, including occult metastases, is crucial for early-stage TNBC.

Purpose of the Study:

  • To investigate the prognostic impact of ALNI in early TNBC.
  • To specifically evaluate the role of small axillary metastases (occult vs. macrometastases).
  • To identify independent prognostic factors for disease-free survival (DFS) and overall survival (OS) in TNBC.

Main Methods:

  • Multicentre study of 1237 patients treated for early TNBC.
  • Analysis of clinicopathological data and ALNI, differentiating between macrometastases and occult metastases (isolated tumor cells or micrometastases).
  • Exploration of ALNI's prognostic value for DFS and OS.

Main Results:

  • Independent prognostic factors for DFS included tumor size >20mm, lymphovascular invasion, and ALNI (both occult and macrometastases).
  • DFS and OS were similar between occult metastases and macrometastases.
  • Patients with at least two adverse features (ALNI, lymphovascular invasion, large tumor size) had significantly poorer DFS and lower 5-year OS (70% vs. >=90%).

Conclusions:

  • Axillary lymph node involvement, including occult metastases, is a critical prognostic factor in early TNBC.
  • The prognostic impact of ALNI is independent of chemotherapy administration.
  • Identifying patients with multiple adverse features can guide risk stratification and treatment decisions.