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Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

666
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

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Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
302
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

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Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

529
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
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Assessing Bacterial Invasion of Cardiac Cells in Culture and Heart Colonization in Infected Mice Using Listeria monocytogenes
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Culture Negative Infective Endocarditits: a Changing Paradigm.

A Daly1, J M Redmond1, M M Hannan2

  • 1Department of Cardiothoracic Surgery, Mater Misercordiae University Hospital, Eccles St, Dublin 7.

Irish Medical Journal
|September 30, 2016
PubMed
Summary
This summary is machine-generated.

Culture negative infective endocarditis (CNIE) poses diagnostic challenges. Molecular diagnostics may alter CNIE epidemiology, as shown by the first reported case of Tropheryma whipplei infective endocarditis in Ireland.

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Diagnostics

Background:

  • Infective endocarditis (IE) diagnosis traditionally relies on modified Duke's criteria, emphasizing positive blood cultures.
  • A significant proportion of IE cases (31%) are classified as culture-negative infective endocarditis (CNIE), complicating treatment.
  • Empiric broad-spectrum antibiotics in CNIE risk compromising targeted therapy due to unidentified pathogens.

Purpose of the Study:

  • To investigate the impact of molecular diagnostic techniques on the epidemiology of CNIE.
  • To report the first case of Tropheryma whipplei infective endocarditis (TWIE) in Ireland.

Main Methods:

  • Review of diagnostic criteria for IE and CNIE.
  • Analysis of the role of molecular diagnostic technologies in identifying causative agents of CNIE.
  • Case presentation of Tropheryma whipplei infective endocarditis.

Main Results:

  • Molecular diagnostics offer potential for identifying pathogens in CNIE, influencing epidemiological understanding.
  • The first documented case of Tropheryma whipplei infective endocarditis in Ireland is presented.

Conclusions:

  • The increasing use of molecular diagnostics may reshape the landscape of CNIE.
  • Early identification of pathogens like Tropheryma whipplei through advanced techniques is crucial for effective IE management.