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Resveratrol in lung cancer- a systematic review

Yuan Feng¹, Jihing Zhou, Ying Jiang

¹Department of Respiratory Medicine, Ruikang Hospital affiliated to Guangxi Traditional Chinese Medicine University, Nanning 530011, Guangxi, China.

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology

|September 30, 2016

Abstract

Purpose:

Resveratrol, a phytochemical known for its anti- oxidative properties has been explored worldwide for anticancer potential. We performed this systematic review and meta-analysis in order to register the efficacy of resveratrol against lung carcinogenesis.

Methods:

We searched PubMed for preclinical studies reporting efficacy of resveratrol alone or in combination with drugs like curcumin, cisplatin etc. against lung carcinogenesis.

Results:

The primary outcome of eligible studies included change in overall tumor incidence as well as tumor size. In all of the above studies involving either animal models or in vitro cancer cell experiments a statistically significant reduction in tumor incidence emerged as compared with the control groups, yielding a relative risk reduction of 0.64 (p=0.002). This meta- analysis confirmed the potential of resveratrol against lung carcinogenesis.

Conclusion:

It can be concluded that resveratrol holds a good potential for future use as a highly efficient therapeutic agent to deal with deadly lung carcinogenesis.

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