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Immunometabolic circuits in trained immunity.

Rob J W Arts1, Leo A B Joosten1, Mihai G Netea1

  • 1Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.

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Summary
This summary is machine-generated.

Innate immune memory, or trained immunity, enhances resistance to reinfection by altering cellular metabolism and epigenetic programming. This discovery offers new avenues for vaccine development and treating immune disorders.

Keywords:
EpigeneticsGlycolysisImmunometabolismMacrophageMonocyteTrained immunity

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Area of Science:

  • Immunology
  • Cellular Metabolism
  • Epigenetics

Background:

  • The traditional understanding attributed immunological memory solely to adaptive immunity.
  • Recent findings indicate that innate immunity also exhibits memory, termed trained immunity.
  • Trained immunity enhances host defense against reinfections.

Purpose of the Study:

  • To explore the mechanisms underlying trained immunity.
  • To investigate the role of cellular metabolism in epigenetic reprogramming for trained immunity.
  • To highlight the therapeutic potential of trained immunity.

Main Methods:

  • Investigated metabolic shifts, including glucose and glutamine metabolism, and cholesterol synthesis.
  • Examined epigenetic modifications associated with trained immunity.
  • Analyzed immunological signals driving these changes.

Main Results:

  • Cellular metabolic rewiring is a key epigenetic driver of trained immunity.
  • Specific metabolic pathways, such as aerobic glycolysis and altered glutamine metabolism, are crucial.
  • Cholesterol synthesis also plays a significant role in establishing trained immunity.

Conclusions:

  • Trained immunity represents a form of innate immune memory.
  • Metabolic reprogramming is central to the epigenetic basis of trained immunity.
  • Trained immunity has significant implications for novel vaccines and therapies for immune-related diseases.