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Metal Nanomaterial Toxicity Variations Within the Vascular System
Alaeddin B Abukabda1,2, Phoebe A Stapleton3, Timothy R Nurkiewicz4,5
1Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, 1 Medical Center Drive, Robert C. Byrd Health Sciences Center, Morgantown, WV, 26505-9105, USA.
Current Environmental Health Reports
|October 1, 2016
Summary
Engineered nanomaterials (ENM) pose risks to human health, particularly the cardiovascular system. Further research is needed to understand ENM cardiovascular toxicity mechanisms.
Area of Science:
- Nanotoxicology
- Cardiovascular Toxicology
- Materials Science
Background:
- Engineered nanomaterials (ENM) are increasingly used in various applications, raising safety concerns due to limited toxicological data.
- Metal and metal oxide ENM are of particular concern for human health due to their potential toxicity.
- Existing research shows adverse systemic effects of ENM, but a clear mechanistic framework for cardiovascular morbidity is lacking.
Purpose of the Study:
- To review the influence of ENM physicochemical characteristics and hemodynamic factors on cardiovascular toxicity.
- To present the toxicity of metallic and metal oxide ENM concerning the cardiovascular system.
- To identify future research directions in cardiovascular nanotoxicology.
Main Methods:
- Literature review focusing on ENM cardiovascular toxicity.
- Analysis of ENM physicochemical properties and hemodynamic factors.
- Examination of metallic and metal oxide ENM effects on cardiovascular components.
Main Results:
- ENM physicochemical properties and hemodynamic factors significantly influence cardiovascular toxicity.
- Metallic and metal oxide ENM exhibit specific toxic effects on the cardiovascular system.
- The field of cardiovascular nanotoxicology is nascent, requiring more research.
Conclusions:
- Understanding ENM cardiovascular toxicity requires integrating knowledge of ENM properties and cardiovascular physiology.
- Continued research is crucial to elucidate the mechanisms linking ENM exposure to cardiovascular disease.
- Addressing knowledge gaps in cardiovascular nanotoxicology is essential for public health protection.
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