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Predictive Value of C-Reactive Protein for Complications Post-Laparoscopic Roux-En-Y Gastric Bypass
Murray R Williams1, Samuel McMeekin2, R Jonathan T Wilson3
1Department of Surgery, York Teaching Hospitals NHS Trust, York, UK. murray.williams@york.nhs.uk.
Obesity Surgery
|October 1, 2016
Summary
C-reactive protein (CRP) levels on postoperative day 2 can predict early complications after laparoscopic roux-en-Y gastric bypass (LRYGB) surgery. Elevated CRP may indicate the need for further investigation in morbidly obese patients.
Area of Science:
- Bariatric Surgery
- Surgical Complications
- Biomarkers
Background:
- Laparoscopic roux-en-Y gastric bypass (LRYGB) is a common procedure for morbid obesity.
- Early detection of postoperative complications is challenging.
- Current diagnostic methods have limitations.
Purpose of the Study:
- To evaluate C-reactive protein (CRP) as a predictor of early postoperative complications.
- To assess CRP levels on postoperative day 1 (POD 1) and POD 2.
- To determine if CRP can guide clinical decisions regarding patient management.
Main Methods:
- Retrospective observational study of 138 patients undergoing LRYGB.
- Data collected from the York bariatric database (2010-2015).
- Exclusion criteria included dual procedures, open conversion, and missing CRP data.
Main Results:
- 10.8% of patients experienced minor complications, and 5.6% had major complications.
- A CRP level > 127 mg/L on POD 2 predicted complications with 93% sensitivity.
- Diagnostic accuracy for CRP on POD 2 was 0.82.
Conclusions:
- CRP on POD 2 is a reliable predictor of both minor and major complications.
- CRP measurements can assist clinicians in identifying patients requiring further investigation.
- This biomarker aids in decisions about patient discharge and follow-up.
