Physician trust and depression influence adherence to factor replacement: a single-centre cross-sectional study
Summary
Patient trust in physicians and managing depression are key factors influencing adherence to factor replacement therapy in adults with haemophilia. Addressing these can improve treatment outcomes and reduce joint damage.
Area of Science:
- Hematology
- Patient Adherence Research
Background:
- Poor adherence to factor replacement therapy in haemophilia patients leads to joint bleeding and disability.
- Optimizing adherence is crucial for managing haemophilia and preventing long-term complications.
Purpose of the Study:
- To identify patient-related characteristics associated with adherence to factor replacement therapy in adults with haemophilia.
- To understand factors that promote or hinder consistent treatment in this population.
Main Methods:
- Cross-sectional study involving adult haemophilia patients.
- Adherence measured using the Validated Hemophilia Regimen Treatment Adherence Scale (VERITAS)-Pro and VERITAS-PRN.
- Regression analyses used to determine associations between patient characteristics and adherence.
Main Results:
- Higher adherence was associated with being on chronic medication, longer treatment center follow-up, greater physician trust, and better quality of life.
- A history of depression was linked to lower adherence.
- Most patients had functional health literacy, but numeracy was low.
Conclusions:
- Physician trust and depression are modifiable factors impacting adherence to factor replacement therapy.
- Enhancing patient-provider trust and addressing depression can improve adherence and reduce joint destruction in haemophilia patients.
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