Benign Glandular Schwannoma in Basal Ganglia

The oncogenesis and biologic behaviors of benign glandular schwannoma have not been clinically unveiled because of its rarity and variability.

However, we report a young male patient who presented with a benign glandular schwannoma in the basal ganglia, a site that has not been reported in any literature. Histologically, the samples are composed of spindle-shaped cells and variable glandular structures. The spindle-shaped cells are identified with the appearance of Antoni A and Antoni B zones. Moreover, the glandular structures are lined by stratified epithelial cells, glandular epithelium cells, intestinal epithelial cells, and few degenerative syncytial macrophage cells. Hemorrhage, necrosis and cystic changes were observed in the specimen cells, but no mitotic figures were found. The immunohistochemical results showed that the spindle cells were stained with S-100 protein, but lacked carcinoembryonic antigen (CEA), cytokeratin pan (AE1/AE3) (CK), synaptophysin, chromogranin A, and glial fibrillary acidic protein reactivity after surgery. Meanwhile, the glandular epithelium cells mostly consisted of glandular epithelium and stratified epithelium cells stained with CEA, chromogranin A, and CK antigen.

Therefore, the morphologic and immunohistochemical findings support the diagnosis of benign glandular schwannoma.