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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Related Experiment Video

Updated: Mar 14, 2026

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
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Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

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Long Non-Coding RNA: An Emerging Paradigm of Pancreatic Cancer.

T Han, H Hu, M Zhuo

  • 1Department of Medical Oncology and Pancreatic Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Pancreatic Diseases, 650 New Songjiang Road, Shanghai 201620, China. jiao_f@outlook.com.

Current Molecular Medicine
|October 1, 2016
PubMed
Summary

Pancreatic cancer is a major global health challenge. This review highlights long non-coding RNAs (lncRNAs) as crucial players in pancreatic cancer development and potential biomarkers for early diagnosis and treatment.

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Last Updated: Mar 14, 2026

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Pancreatic cancer presents significant global health challenges due to low surgical resection rates and resistance to chemotherapy.
  • Early diagnosis and treatment are critical for improving patient outcomes.
  • Historically, research focused on protein-coding genes, overlooking the role of non-coding regions.

Purpose of the Study:

  • To review the role of functional long non-coding RNAs (lncRNAs) in pancreatic cancer.
  • To elucidate the mechanisms by which lncRNAs contribute to carcinogenesis.
  • To explore the diagnostic and prognostic significance of lncRNAs in pancreatic cancer.

Main Methods:

  • Literature review of studies on lncRNAs in pancreatic cancer.
  • Analysis of lncRNA functions including cell proliferation, migration, invasion, metastasis, and chemo-resistance.
  • Summary of proposed lncRNA regulatory mechanisms (signaling, decoy, guide, scaffold).

Main Results:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized as key regulators in cancer development.
  • Dysregulated lncRNAs have been identified in pancreatic cancer, influencing critical biological processes.
  • lncRNAs offer potential as novel biomarkers for pancreatic cancer diagnosis and prognosis.

Conclusions:

  • lncRNAs play significant roles in the pathogenesis of pancreatic cancer.
  • Understanding lncRNA mechanisms can reveal new therapeutic targets.
  • Further research into lncRNAs is essential for advancing pancreatic cancer management.