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Hand osteoarthritis: current knowledge and new ideas
1a Department of Rheumatology , Diakonhjemmet Hospital , Oslo , Norway.
Scandinavian Journal of Rheumatology
|October 1, 2016
Summary
Hand osteoarthritis (OA) affects many, causing pain and disability. Research shows synovitis (inflammation) detected by MRI and ultrasound is linked to pain and disease progression, suggesting it as a treatment target.
Area of Science:
- Rheumatology and Osteoarthritis Research
- Epidemiology of Musculoskeletal Diseases
Background:
- Hand osteoarthritis (OA) is a common condition causing significant pain and disability.
- Current treatments for OA do not modify disease progression, and research often focuses on knee OA, leaving hand OA mechanisms less understood.
Purpose of the Study:
- To investigate the epidemiology of hand OA and explore novel imaging techniques for assessing inflammation.
- To identify potential treatment targets for hand OA, focusing on synovitis.
Main Methods:
- Analysis of epidemiological data from international OA cohorts, including the Framingham study.
- Evaluation of magnetic resonance imaging (MRI) for reliability and validity in hand OA, leading to a developed MRI scoring system.
- Utilizing MRI and ultrasound to detect synovitis and correlate it with pain and disease progression.
Main Results:
- Symptomatic hand OA prevalence was found to be 16% in women and 8% in men (aged 40-84) in the Framingham study.
- MRI is more sensitive than radiographs for detecting structural abnormalities in hand OA.
- Synovitis, identified via MRI and ultrasound, is associated with pain and predicts future hand OA progression.
Conclusions:
- Synovitis is a key factor in hand OA, linked to pain and progression, making it a potential therapeutic target.
- Future research includes the Nor-Hand study focusing on pain causes and inflammation imaging, and a clinical trial investigating methotrexate (MTX) for hand OA treatment.
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