Related Experiment Video
Updated: Mar 14, 2026

Live-cell Imaging of Sensory Organ Precursor Cells in Intact Drosophila Pupae
Published on: May 27, 2011
Nuf and Rip11 requirement for polarity determinant recycling during Drosophila development
Francisco J Calero-Cuenca1, Sol Sotillos1
1a CABD , CSIC/JA/UPO, Campus Universidad Pablo de Olavide , Sevilla , Spain.
Abstract:
A tight relationship between apico-basal polarity and trafficking is essential for epithelial physiology and tissue homeostasis. Recent studies have described how some Rab GTPases, key components of the intracellular traffic machinery, contribute to the establishment of cell polarity in vertebrates. We have demonstrated a novel connection between cell polarity and trafficking: in Drosophila epithelia, the apical determinant aPKC is recycled via Rab11-Nuf-recycling endosomes to maintain cell polarity. Furthermore, the phosphorylation of Nuf by aPKC allows aPKC to control the sub-cellular localization of Nuf and its own membrane accumulation. Here we review these data and show the different contribution of the 2 Drosophila Rab11 adaptor proteins, Nuf and Rip11, to the maintenance of Drosophila embryonic ectoderm polarity.
Related Concept Videos
The Ratio of X Chromosome to Autosomes
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Cell Polarization by Rho Proteins
Cis-regulatory Sequences

