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First-in-man observation of Talaromyces marneffei-transmission by organ transplantation

Frederik Hermans1, Sien Ombelet2,3, Karlien Degezelle4

  • 1Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.

Mycoses
|October 1, 2016
PubMed

Insights

A lung transplant recipient contracted penicilliosis from a donor, highlighting a rare fungal infection transmission route. Increased vigilance is needed for unusual pathogen transmission in organ recipients due to global travel.

Area of Science:

  • Medical Mycology
  • Transplant Infectious Diseases
  • Public Health

Background:

  • Organ transplantation, while life-saving, carries risks of infectious complications.
  • Talaromyces marneffei is a fungus endemic in Southeast Asia, causing penicilliosis.
  • Global travel and organ donor networks increase the potential for pathogen dissemination.

Observation:

  • A lung transplant recipient developed penicilliosis caused by Talaromyces marneffei.
  • The infection was traced to transmission from the organ donor.
  • This represents the first documented case of Talaromyces marneffei transmission via lung transplantation.

Findings:

  • Donor-derived Talaromyces marneffei infection is a potential complication in lung transplant recipients.
  • The case highlights the limitations of donor screening for certain endemic fungal pathogens.
  • Globalization and increased international travel facilitate the spread of rare infectious agents.

Implications:

  • Enhanced surveillance and diagnostic awareness are crucial for identifying unusual infections in transplant recipients.
  • Current screening protocols may need re-evaluation to address geographically specific endemic pathogens.
  • This case underscores the need for heightened vigilance regarding infectious disease transmission in the era of globalized transplantation and travel.
Keywords:
emerging diseasefungal infectioninfection by mode of transmissionlung transplantationpenicilliosiszoonotic infection

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