Related Experiment Video
Updated: Mar 14, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
[Expression of CDK6 in early ovarian cancer and its clinical significance]
Objective:
To explore the expression of CDK6 in early ovarian cancer and explore its clinical significance.
Methods:
Real-time PCR and immunohistochemistry was used to examine the differential expression of CDK6 mRNA and protein in ovarian cancer and normal ovarian tissues. The correlation of CDK6 expression with the clinical characteristics and prognosis of the patients was analyzed.
Results:
The expression of CDK6 mRNA was obviously up-regulated in 36 ovarian cancer tissues as compared to that in 16 ovarian tissues. Immunohistochemistry demonstrated that CDK6 protein was expressed in both the cytoplasm and cell nuclei. Compared with the 48 normal ovarian tissues, the 121 ovarian cancer tissues showed significantly up-regulated CDK6 protein expression (P=0.044). Increased CDK6 protein expression was not significantly correlated with the clinical features of the patients with ovarian cancer, but showed a significant negative correlation with the patients' prognosis (P=0.006). Multivariate analysis suggested that CDK6 expression level was an independent prognostic indicator (P=0.008) for the survival of patients with ovarian cancer.
Conclusion:
Increased CDK6 protein expression may promote the development and progression of early ovarian cancer.
Related Concept Videos
Inhibition of Cdk Activity
M-Cdk Drives Transition Into Mitosis
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Positive Regulator Molecules
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

