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Updated: Aug 14, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Subtle encephalomyelitis in children: a variant of acute disseminated encephalomyelitis

S D Johnsen1, A D Sidell, C R Bird

  • 1Section of Child Neurology, Barrow Neurological Institute, St. Joseph's Hospital, Phoenix, AZ 85013-4476.

Journal of Child Neurology
|July 1, 1989
PubMed

Insights

Four children with unexplained neurological symptoms showed white-matter lesions on MRI, suggesting acute disseminated encephalomyelitis. These cases resolved spontaneously, offering insights into demyelinating diseases.

Area of Science:

  • Neurology
  • Pediatrics
  • Radiology

Background:

  • Describes four pediatric cases with chronic, mild, nonspecific neurological symptoms.
  • Symptoms included headaches, irritability, clumsiness, and personality changes over several months.

Observation:

  • Magnetic resonance imaging (MRI) revealed multifocal white-matter lesions suggestive of acute disseminated encephalomyelitis.
  • Physical examinations and laboratory investigations did not identify other causes for demyelination.

Findings:

  • All four children recovered spontaneously without specific treatment, with complete resolution of symptoms.
  • The white-matter lesions may indicate exposure to a subtle myelinolytic antigen.

Implications:

  • This exposure might confer resistance to subsequent infections or immunizations, potentially explaining varied disease progression.
  • Further multicenter studies are recommended to explore the etiopathogenesis of multiple sclerosis and similar demyelinating conditions.

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