Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pigmentation01:19

Pigmentation

4.9K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.9K
Skin Cancer01:30

Skin Cancer

6.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.5K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.1K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.1K
Papillary Dermis01:11

Papillary Dermis

6.6K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.6K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.0K
Pleiotropy01:33

Pleiotropy

43.9K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BBB permeable selective HDAC3 inhibitor SP108 restores hippocampal plasticity and learning in a MAM-induced model of schizophrenia.

Neuropharmacology·2026
Same author

Role of persistent necroinflammation in chronic tissue remodeling and organ fibrosis.

American journal of physiology. Cell physiology·2025
Same author

Effect of New Coumarin-Ferulate Cyclic Conjugates on Acute Kidney Injury (Oxalate Nephropathy): Synthesis, In Vitro and In Vivo Evaluations.

ChemMedChem·2025
Same author

HPV Vaccines - An Overview.

Indian journal of dermatology·2025
Same author

Whole-body inhalation study of nanoparticle-enhanced vegetable oil metalworking fluids in mice for assessing occupational health risks.

Scientific reports·2025
Same author

Caffeic Acid-Biogenic Amine Complexes Outperform Standard Drugs in Reducing Toxicity: Insights from <i>In Vivo</i> Iron Chelation Studies.

Molecular pharmaceutics·2025

Related Experiment Video

Updated: Mar 14, 2026

Author Spotlight: Non-Surgical Treatment of Melasma&#8211; Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.7K

Lichen Planus Pigmentosus: The Controversial Consensus.

Aparajita Ghosh1, Arijit Coondoo1

  • 1Department of Dermatology, KPC Medical College and Hospital, Kolkata, West Bengal, India.

Indian Journal of Dermatology
|October 1, 2016
PubMed
Summary

Lichen planus pigmentosus (LPP) is a skin condition causing dark patches, primarily on sun-exposed areas, especially in darker skin tones. Its exact relationship to erythema dyschromicum perstans remains debated among dermatologists.

Keywords:
Erythema dyschromicum perstanslichen planuslichen planus pigmentosus

More Related Videos

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.6K
Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells
07:07

Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells

Published on: March 8, 2015

9.8K

Related Experiment Videos

Last Updated: Mar 14, 2026

Author Spotlight: Non-Surgical Treatment of Melasma&#8211; Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.7K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.6K
Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells
07:07

Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells

Published on: March 8, 2015

9.8K

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Lichen planus pigmentosus (LPP) is a pigmented variant of lichen planus first described in India.
  • LPP predominantly affects individuals with darker skin tones and presents with insidious onset of hyperpigmented macules and patches.

Purpose of the Study:

  • To describe the clinical and histopathological features of lichen planus pigmentosus.
  • To discuss the differential diagnosis and controversial identity of LPP with erythema dyschromicum perstans.
  • To report associated conditions and variants of LPP.

Main Methods:

  • Clinical observation and histopathological examination of affected skin.
  • Review of existing literature on LPP and related conditions.

Main Results:

  • LPP typically manifests on sun-exposed areas, sparing palms, soles, and nails.
  • Histopathology reveals epidermal atrophy, basal cell vacuolar degeneration, and dermal pigment incontinence.
  • Significant histopathological similarities exist between LPP and erythema dyschromicum perstans, though clinical and immunological differences are noted.

Conclusions:

  • LPP is a distinct entity, despite histopathological similarities with erythema dyschromicum perstans.
  • Associations with Hepatitis C virus, frontal fibrosing alopecia, Bazex acrokeratosis, and nephrotic syndrome have been reported.
  • A rare variant, LPP inversus, affects covered areas and predominantly white-skinned individuals.