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Chlamydia trachomatis Infection and Photosensitive Dermatoses
Mps Sawhney1, S Arora2, A Khetrapal3
1Senior Advisor (Dermatology & STD), Base Hospital, Delhi Cantt.
Medical Journal, Armed Forces India
|October 1, 2016
Summary
Chlamydia trachomatis infection is linked to photosensitive dermatoses like melasma and chronic actinic dermatitis in non-LGV cases. Investigating C. trachomatis is recommended for these conditions.
Area of Science:
- Dermatology
- Infectious Diseases
- Immunology
Background:
- Photosensitivity is common in Lymphogranuloma Venereum (LGV) caused by Chlamydia trachomatis serovars L1-L3.
- The role of C. trachomatis in photosensitive dermatoses unrelated to LGV remains understudied.
Purpose of the Study:
- To investigate the association between C. trachomatis infection and various photosensitive dermatoses in non-LGV cases.
- To determine if C. trachomatis antibodies are present in patients with photosensitivity, melasma, chronic actinic dermatitis (CAD), polymorphic light eruption (PLE), actinic prurigo (AP), and rosacea.
Main Methods:
- Sera from patients with photosensitive dermatoses and healthy controls were tested for IgM, IgG, and IgA antibodies to C. trachomatis using ELISA.
- Statistical analysis, including chi-squared tests, was employed to compare seropositivity rates.
Main Results:
- Significantly higher seropositivity for C. trachomatis antibodies was found in patients with photosensitivity (25.53%), melasma (25.53%), and CAD (46.15%) compared to controls.
- While higher seropositivity was noted in rosacea and PLE cases, the differences were not statistically significant.
- No association was found between C. trachomatis infection and actinic prurigo.
Conclusions:
- C. trachomatis infection is a significant cause of photosensitivity, melasma, and CAD in non-LGV cases.
- The findings suggest C. trachomatis may also contribute to rosacea and PLE.
- Investigation for C. trachomatis infection is recommended for patients diagnosed with photosensitivity, melasma, CAD, PLE, and rosacea, as well as their sexual contacts.
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