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Updated: Mar 14, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Inositols in the Treatment of Insulin-Mediated Diseases
Giovanna Muscogiuri1, Stefano Palomba2, Antonio Simone Laganà3
1IOS and Coleman Medicina Futura Medical Center, Centro Direzionale, 80143 Naples, Italy.
Abstract:
A growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states. Both isomers have been shown to exert insulin-mimetic action and to lower postprandial glucose. Further, insulin resistance-related diseases were associated to derangements in inositol metabolism. Thus, the aim of this review is to provide current evidence on the potential benefits of inositol isomers (MYO-INS and DCI) in the treatment of disease associated to insulin resistance such as polycystic ovary syndrome (PCOS), gestational diabetes, and metabolic syndrome. Finally, molecular insights into inositol insulin-sensitizing effects will be covered focusing on the possible role of inositol glycans as insulin second messengers.
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