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Updated: Mar 14, 2026

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
Published on: January 7, 2019
Acute Delamination of Commercially Available Decellularized Osteochondral Allograft Plugs: A Report of Two Cases
Ryan M Degen1, Danielle Tetreault1, Greg T Mahony1
1Hospital for Special Surgery, Sports Medicine and Shoulder Service, New York, NY, USA.
Abstract:
Articular cartilage injuries, and corresponding surgical procedures, are occurring with increasing frequency as identified by a review of recent surgical trends. Concerns have grown in recent years regarding the longevity of results following microfracture, with a shift toward cartilage restoration procedures in recent years. This case report describes 2 cases of acute failure following the use of commercially available osteochondral allograft plugs used for the treatment of osteochondral defects of the distal femur. In both cases the chondral surface of the plug delaminated from the underlying cancellous bone, resulting in persistent pain and swelling requiring reoperation and removal of the loose fragments. Caution should be employed when considering use of these plugs for the treatment of osteochondral lesions, as similar outcomes have not been noted with other cartilage restoration techniques.
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