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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Parkinson's Disease: Treatment01:24

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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Epilepsy and Seizures: Overview01:24

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Seizures: Classification01:13

Seizures: Classification

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
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Focal Seizures
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Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Related Experiment Video

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Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
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Parkinson's Disease and Cryptogenic Epilepsy.

Andre Y Son1, Milton C Biagioni1, Dorian Kaminski1

  • 1The Marlene and Paolo Fresco Institute for Parkinson's & Movement Disorders, NYU Langone Medical Center, New York University School of Medicine, New York, NY, USA.

Case Reports in Neurological Medicine
|October 1, 2016
PubMed
Summary

Epilepsy is rarely seen with Parkinson's disease (PD). This study examined five patients with both conditions, suggesting their coexistence might impact PD progression and potentially share underlying mechanisms.

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Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
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Area of Science:

  • Neurology
  • Neuroscience

Background:

  • Epilepsy is an uncommon comorbidity of Parkinson's disease (PD).
  • Historically, PD and epilepsy have not been considered directly associated.
  • Understanding the relationship between these two neurological disorders is crucial.

Purpose of the Study:

  • To report on patients with concomitant Parkinson's disease and cryptogenic epilepsy.
  • To explore the potential influence of coexisting epilepsy on Parkinson's disease progression.
  • To consider possible mechanistic associations between PD and epilepsy.

Main Methods:

  • Case series presentation.
  • Description of five patients (3 male, 2 female; ages 49-85) with concurrent PD and cryptogenic epilepsy.

Main Results:

  • Five cases of concomitant Parkinson's disease and cryptogenic epilepsy were identified.
  • The coexistence of these conditions was observed in the patient cohort.
  • The study highlights the occurrence of this rare comorbidity.

Conclusions:

  • Epilepsy, though rare, can coexist with Parkinson's disease.
  • The combined presence of PD and epilepsy may affect the progression of Parkinson's disease.
  • Further research into the neurophysiological underpinnings may reveal mechanistic links between these conditions.