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Updated: Mar 14, 2026
08:11
Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria
Published on: July 6, 2013
13.4K
Targeted Cancer Therapy Using Engineered Salmonella typhimurium
Jin Hai Zheng1, Jung-Joon Min2
1Laboratory of In Vivo Molecular Imaging, Institute for Molecular Imaging and Theranostics, Chonnam National University Medical School, Gwangju, Korea.
Chonnam Medical Journal
|October 1, 2016
Summary
Attenuated Salmonella typhimurium (S. typhimurium) bacteria are engineered as cancer therapeutics. These bacteria target tumors, inhibit growth, and can deliver therapeutic cargo, showing promise in clinical trials.
Area of Science:
- Oncology
- Microbiology
- Biotechnology
Background:
- Certain anaerobic bacteria, including Salmonella typhimurium (S. typhimurium), naturally colonize tumors.
- Attenuated S. typhimurium strains are investigated as cancer therapeutics due to their tumor-targeting and growth-inhibiting properties.
Purpose of the Study:
- To review recent advancements in Salmonellae-mediated cancer therapy.
- To highlight the potential of engineered S. typhimurium as a versatile platform for cancer treatment and diagnosis.
Main Methods:
- Review of existing literature on Salmonellae-mediated cancer therapy.
- Discussion of engineered S. typhimurium strains, including VNP20009, and their characteristics.
Main Results:
- Engineered S. typhimurium strains demonstrate tumor-targeting, proliferation within tumors, and deep tissue penetration.
- An attenuated strain, VNP20009, showed promise in Phase I clinical trials for metastatic melanoma and squamous cell carcinoma.
- Genetic manipulability allows for enhanced safety profiles and tailored therapeutic or diagnostic cargo delivery.
Conclusions:
- Salmonellae-mediated cancer therapy holds significant potential, with ongoing research focused on refining efficacy.
- Engineered S. typhimurium offers a flexible platform for developing novel cancer treatment and diagnostic strategies.
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