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Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
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Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
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Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
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Related Experiment Video

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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
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Daptomycin-Vancomycin-Resistant Enterococcus faecium Native Valve Endocarditis: Successfully Treated With Off-Label

Khandakar Hussain1, Saad Ullah1, Hassan Tahir1

  • 1Temple University/Conemaugh Memorial Medical Center, Johnstown, PA, USA.

Journal of Investigative Medicine High Impact Case Reports
|October 1, 2016
PubMed
Summary

Daptomycin-resistant enterococcal infections are a growing threat. This case study explores the successful off-label treatment of a severe infection using quinupristin-dalfopristin when other options failed.

Keywords:
Enterococcal faecalisdaptomycin-resistant enterococciinfective endocarditismultidrug resistancequinupristin-dalfopristin

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Area of Science:

  • Infectious Diseases
  • Internal Medicine
  • Pharmacology

Background:

  • Multidrug-resistant enterococcal infections represent a significant and growing challenge in healthcare settings.
  • Limited therapeutic options exist for treating infections caused by these highly virulent and resistant organisms.
  • Risk factors include prolonged hospitalization, prior antibiotic exposure, and compromised immune systems.

Purpose of the Study:

  • To report a case of daptomycin-resistant enterococcal native infective endocarditis.
  • To describe the successful management of this infection using an off-label therapeutic approach.

Main Methods:

  • A case report detailing a patient with daptomycin-resistant enterococcal native infective endocarditis.
  • Treatment involved the off-label administration of quinupristin-dalfopristin.

Main Results:

  • Successful clinical outcome in a patient with a complex, resistant infection.
  • Demonstration of quinupristin-dalfopristin efficacy in a challenging clinical scenario.

Conclusions:

  • Quinupristin-dalfopristin can be a viable therapeutic option for daptomycin-resistant enterococcal infections, including native infective endocarditis.
  • Off-label use of antibiotics may be necessary when standard treatments are ineffective against multidrug-resistant pathogens.