Related Experiment Video

Updated: Mar 14, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

764

Bronchopulmonary Dysplasia in Preterm Infants Born at Less Than 32 Weeks Gestation

Yan-Ping Xu1

  • 1The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Global Pediatric Health
|October 1, 2016
PubMed

Insights

Bronchopulmonary dysplasia (BPD) in preterm infants is linked to early pulmonary hypertension (PH). Prolonged oxygen and ventilator use, along with vascular disease, increase the risk of severe BPD and PH.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Cardiology

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant chronic respiratory condition in premature infants.
  • Pulmonary hypertension (PH) is a serious complication that can arise in infants with BPD.

Purpose of the Study:

  • To investigate factors associated with early pulmonary hypertension (PH) in preterm infants.
  • To examine echocardiographic evidence of PH in moderate to severe bronchopulmonary dysplasia (BPD).

Main Methods:

  • Retrospective review of preterm infants (<32 weeks gestation) admitted between July 2013 and July 2015.
  • Analysis of clinical data including duration of ventilator and oxygen support.
  • Classification of BPD severity (mild, moderate, severe).

Main Results:

  • Forty-two preterm infants were included in the study.
  • Infants who developed PH required longer durations of ventilator and oxygen therapy.
  • Severe BPD at 28 days was associated with the presence of pulmonary hypertension.

Conclusions:

  • Early pulmonary vascular disease and persistent infections contribute to severe BPD.
  • Findings suggest a link between prolonged respiratory support, vascular complications, and PH in preterm infants with BPD.
Abstract

Keywords:
bronchopulmonary dysplasiaprematurity

More Related Videos

Intratracheal Instillation of Stem Cells in Term Neonatal Rats04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

6.2K
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K

Related Concept Videos

Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
4.5K
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
66.0K
Pneumothorax-I01:26

Pneumothorax-I

A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
1.9K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.0K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
1.2K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.4K