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Early prediction of renal parenchymal injury with serum procalcitonin

Leila Barati1, Baranak Safaeian1, Mahshid Mehrjerdian1

  • 1Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Journal of Renal Injury Prevention
|October 1, 2016
PubMed

Insights

Serum procalcitonin (PCT) effectively predicts renal parenchymal injuries in children with febrile urinary tract infections (UTIs). This inflammatory marker shows good accuracy, aiding early detection and management of potential kidney damage in pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Biomarkers

Background:

  • Urinary tract infections (UTIs) are common in children and can lead to renal scarring.
  • Dimercaptosuccinic acid (DMSA) renal scan is the standard for diagnosing acute pyelonephritis but has limitations.

Purpose of the Study:

  • To evaluate serum procalcitonin (PCT) as an early predictor of renal injuries in children with febrile UTI.
  • To assess the accuracy of PCT compared to DMSA scan.

Main Methods:

  • Prospective study of 95 children with their first febrile UTI.
  • Serum PCT levels were measured and analyzed against DMSA scan results.
  • Calculated sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for PCT.

Main Results:

  • PCT levels were significantly higher in children with renal parenchymal injuries (P<0.0001).
  • PCT demonstrated a sensitivity of 70%, specificity of 88.1%, PPV of 88.1%, and NPV of 70%.
  • The positive likelihood ratio (PLR) for PCT was 5.8.

Conclusions:

  • Serum PCT is a valuable inflammatory marker for predicting renal parenchymal injuries in pediatric UTI.
  • PCT shows promising accuracy and is particularly relevant for children under 24 months.
  • Further research is recommended to confirm these findings.
Abstract

Keywords:
ChildrenProcalcitoninUrinary tract infection

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