Related Experiment Video
Updated: Mar 14, 2026

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
Published on: June 21, 2015
Effect of aerobic exercise against vanadyl sulphate-induced nephrotoxicity and hepatotoxicity in rats
Fatemeh Ahmadi1, Mehdi Nematbakhsh2, Mehdi Kargarfard3
1Water & Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Sport Physiology, University of Isfahan, Isfahan, Iran.
Introduction:
Vanadium compounds are insulin like drugs which are accompanied with nephrotoxicity and hepatotoxicity as their major side effects. Aerobic exercise is well known as an approach to reduce the side effects of many drugs.
Objectives:
This study was designed to determine the role of aerobic exercise against vanadyl sulphate induced nephrotoxicity and hepatotoxicity in male rats.
Materials And Methods:
Twenty-four male Wistar rats were randomly divided into three groups. Group I had aerobic exercise on a treadmill 5 days/week for 6 weeks. Group II received vanadyl sulphate (50 mg/kg/week; i.p.) for 6 weeks. Group III had combination of exercise and vanadyl sulphate therapy as groups 1 and 2. At the end of study, blood samples were obtained, and the animals were sacrificed for the tissues injury determination.
Results:
Vanadyl sulphate alone increased serum levels of blood urea nitrogen (BUN), creatinine (Cr), and kidney weight (KW) and kidney tissue damage score (KTDS) (P<0.05). These observations revealed nephrotoxicity induced by vanadyl sulphate, although exercise training did not attenuate these results. In addition, vanadyl sulphate alone induced liver tissue damage score and exercise training intensified it insignificantly, while the serum levels of aspartate amino transferase and alanine amino transferase were greater in exercise alone group than others groups.
Conclusion:
Aerobic exercise could not attenuate vanadyl sulphate induced nephrotoxicity and hepatotoxicity. These findings must be considered when vanadyl sulphate is suggested as insulin like drug.
More Related Videos
08:505/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
06:32Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions
Published on: June 13, 2025
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Drug Toxicity: Dose-Dependent Reactions
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Toxicity Testing in Animals
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug