[Transplantation of gynecologic tumor in nude mice]

Seventy-four cases of gynecologic tumor; 29 of the endometrium, 20 of the ovary, 9 of the trophoblastic, 7 of the cervix, 2 of the fallopian tube and one of the vulva, and 6 of malignant ascites, were transplanted into nude mice. 1. Overall success rate at the trial of primary transplantation revealed 35.1% or 26 cases out of 74. Trophoblastic neoplasia appeared the highest in the rate among each tumors, showing 55.5% of 9 trials. 2. Out of 26 successful cases of the primary trials, 14 or 53.8% are serially transplantable. These consisted of 7 endometrial, 2 ovarian, 3 choriocarcinoma and 2 cervical carcinomas. 3. The serially transplantable tumors are reproducible of the morphology of each original tumor. 4. The doubling times of the tumor size in choriocarcinoma are evenly short although life span of the tumor-bearing mice varies from each other. Endometrial and ovarian carcinomas spend the time longer than choriocarcinoma. The doubling times differ from each case of endometrial carcinoma with the same histological grade. 5. Choriocarcinoma lines preserve hCG secreting ability. Tumor size of the choriocarcinoma originated from the kidney correlates well with its serum hCG titer. These lines of gynecologic malignancy serially transplantable in nude mice will be useful for further cancer research.