Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sol-gel derived B<sub>2</sub>O<sub>3</sub>-CaO borate bioactive glasses with hemostatic, antibacterial and pro-angiogenic activities.

Regenerative biomaterials·2024
Same author

Editorial: Bioengineering of biomimetic microenvironments for cardiac tissue engineering.

Frontiers in bioengineering and biotechnology·2023
Same author

The Impact of 45S5-Bioactive Glass on Synovial Cells in Knee Osteoarthritis-An In Vitro Study.

Materials (Basel, Switzerland)·2023
Same author

Bioactive Glass and Silica Particles for Skeletal and Cardiac Muscle Tissue Regeneration.

Tissue engineering. Part B, Reviews·2023
Same author

Surface engineering of mesoporous bioactive glass nanoparticles with bacteriophages for enhanced antibacterial activity.

Colloids and surfaces. B, Biointerfaces·2023
Same author

Mending a broken heart by biomimetic 3D printed natural biomaterial-based cardiac patches: a review.

Frontiers in bioengineering and biotechnology·2023

Related Experiment Video

Updated: Mar 14, 2026

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells
06:17

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells

Published on: March 28, 2025

1.2K

Poly(3-hydroxyoctanoate), a promising new material for cardiac tissue engineering.

Andrea V Bagdadi1, Maryam Safari1, Prachi Dubey1

  • 1Applied Biotechnology Research Group Faculty of Science and Technology, University of Westminster, London, UK.

Journal of Tissue Engineering and Regenerative Medicine
|October 1, 2016
PubMed
Summary

Poly(3-hydroxyoctanoate) (P(3HO)) shows promise as a new material for cardiac tissue engineering. P(3HO) patches exhibit suitable mechanical properties and excellent biocompatibility for cardiac cell regeneration.

Keywords:
Poly(3-hydroxyoctanoate)cardiac patchescardiac tissue engineeringpolyhydroxyalkanoates

More Related Videos

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.7K
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

11.0K

Related Experiment Videos

Last Updated: Mar 14, 2026

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells
06:17

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells

Published on: March 28, 2025

1.2K
Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.7K
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

11.0K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Cardiac tissue engineering (CTE) addresses a significant clinical need for cardiac repair.
  • Developing novel biomaterials is crucial for creating functional cardiac constructs.
  • Polyhydroxyalkanoates (PHAs) are biodegradable polymers with potential biomedical applications.

Purpose of the Study:

  • To investigate poly(3-hydroxyoctanoate) (P(3HO)), a medium chain-length PHA, as a novel material for CTE.
  • To engineer P(3HO) constructs with improved mechanical properties and surface topography for cardiac regeneration.
  • To assess the biocompatibility and cellular response of P(3HO) for cardiac applications.

Main Methods:

  • Bacterial fermentation was used to produce P(3HO).
  • Engineered P(3HO) patches with controlled mechanical properties and surface topography were fabricated.
  • Biocompatibility was assessed using neonatal rat ventricular myocytes (NVRM) and adult cardiomyocytes.
  • Cell viability, proliferation, adhesion, and cardiomyocyte contraction were evaluated.

Main Results:

  • P(3HO) patches demonstrated mechanical properties comparable to native cardiac muscle.
  • P(3HO) exhibited excellent biocompatibility, with cell viability, proliferation, and adhesion similar to collagen.
  • Porous and fibrous P(3HO) structures enhanced cell adhesion and proliferation.
  • No adverse effects on adult cardiomyocyte contraction were observed.

Conclusions:

  • P(3HO)-based multifunctional cardiac patches are promising for efficient CTE.
  • P(3HO) and other PHAs represent a novel class of biodegradable functional materials for biomedical applications.
  • This research highlights the potential of P(3HO) in advancing cardiac regenerative therapies.