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Updated: Mar 14, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
One new flavanocoumarin from the thorns of Gleditsia sinensis
Jinqian Yu1, Yunxia Xian2, Gang Li2
1a Shandong Key Laboratory of TCM Quality Control Technology , Shandong Analysis and Test Center , Jinan , P.R. China.
Abstract:
One new flavanocoumarin (1), as well as six known flavonoids (2-7), was isolated from the ethyl acetate extract of the thorns of Gleditsia sinensis. The structures of these compounds were elucidated by extensive spectroscopic measurements and comparison with data reported in literatures. Cytotoxic activities of compounds 1-6 were evaluated against human liver cancer SK-hep-1 cells in vitro by the MTT method, with compound 1 displaying moderate activity (IC50 of 62.53 μM). Furthermore, compound 1 could increase the number of apoptosis cells in a concentration-dependent manner.
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