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Updated: Aug 10, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
[When do we have to treat chronic leukemia?]
Insights
Treatment decisions for chronic lymphocytic leukemia (CLL) and chronic myelocytic leukemia (CML) are complex. Recent advancements in CLL classification aid therapeutic clarity, while CML chemotherapy manages symptoms but doesn't significantly extend survival.
Area of Science:
- Hematology
- Oncology
Abstract:
The grounds for treating or not treating chronic lymphocytic leukemias (CLL) and chronic myelocytic leukemias (CML) are discussed in the light of results in recent years. In the case of CLL, objective evaluation of treatment benefits has hitherto been difficult due to the heterogeneity of this group of diseases. A recent classification, based on hematological and clinical parameters and apparently of prognostic value, will undoubtedly help to clarify the therapeutic problem. In the case of CML, routine chemotherapy programs certainly alleviate the symptoms of the disease but have not so far achieved a significant prolongation of survival.
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