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A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

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Quantitative ¹⁷⁷Lu SPECT imaging using advanced correction algorithms in non-reference geometry.

M D'Arienzo¹, M L Cozzella², A Fazio²

¹ENEA, National Institute of Ionizing Radiation Metrology, Via Anguillarese 301, 00123 Rome, Italy; Department of Human Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Via Borelli 50, 00161 Rome, Italy.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)

|October 4, 2016

Summary

This summary is machine-generated.

Accurate quantification of ¹⁷⁷Lu activity in neuroendocrine tumors is achievable with advanced SPECT corrections. This method ensures reliable measurements for peptide receptor therapy, crucial for treatment effectiveness.

Keywords:

Correction algorithms PRRT with (177)Lu-labelled somatostatin analogue Quantitative imaging Transmission-dependent convolution-subtraction correction algorithm

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Area of Science:

Nuclear Medicine
Medical Imaging
Radiopharmaceutical Therapy

Background:

Peptide receptor therapy using ¹⁷⁷Lu-labelled somatostatin analogues is vital for treating advanced neuroendocrine tumors.
Accurate activity quantification is essential for effective dosimetry and treatment planning.

Purpose of the Study:

To develop and validate accurate quantification methods for ¹⁷⁷Lu activity in complex geometries using Single Photon Emission Computed Tomography (SPECT).
To assess the impact of advanced correction algorithms on quantitative accuracy.

Main Methods:

SPECT acquisitions using a Philips IRIX gamma camera at the 208keV photopeak with medium-energy collimators.
System calibration with a Jaszczak phantom; corrections for attenuation (μ-maps), scatter, septal penetration, dead time, and partial volume effects.
Validation using an anthropomorphic phantom with simulated hepatic lesions and varying tumor-to-background ratios (6:1, 9:1, 14:1).

Main Results:

Recovered total ¹⁷⁷Lu activity was within 12% of calibrated activity in both background and simulated tumor regions.
With a 6:1 tumor-to-background ratio, accuracy improved to within 2% in the tumor and 5% in the background.
Partial volume effects significantly underestimate activity if not corrected.

Conclusions:

Accurate ¹⁷⁷Lu quantification is feasible with traceable equipment, advanced SPECT correction algorithms, and optimized acquisition protocols (208keV photopeak, medium-energy collimators).
Proper correction for partial volume effects is critical for reliable clinical dosimetry in peptide receptor radionuclide therapy.