Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffuse axonal injury in head trauma.

P C Blumbergs1, N R Jones, J B North

  • 1Neuropathology Laboratory, Royal Adelaide Hospital, South Australia.

Journal of Neurology, Neurosurgery, and Psychiatry
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinal photoreceptor damage produced in guinea pigs by tunicamycin.

Australian veterinary journal·2020
Same author

Learning from regret.

The British journal of surgery·2020
Same author

The potential of recycled materials used in agriculture to contaminate food through uptake by livestock.

The Science of the total environment·2019
Same author

Processes of care in surgical patients who died with hospital-acquired infections in Australian hospitals.

The Journal of hospital infection·2017
Same author

Characterization of an 'Amyloid Only' Transgenic (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) Mouse Model of Alzheimer's Disease.

Journal of comparative pathology·2017
Same author

Predictors of mortality in patients with femoral neck fracture.

Journal of orthopaedic surgery (Hong Kong)·2016
Same journal

Diagnostic accuracy of a two-cut-off approach using the FAQ/MMSE ratio and FAQ for clinical preselection of patients for anti-amyloid therapy.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Cancer risk and mortality in patients with multiple sclerosis in Finland: a retrospective population-based cohort study.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Visuospatial working memory in Huntington's disease: behavioural and structural brain correlates.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Characteristics and outcomes in electric scooter-related traumatic brain injuries in Helsinki.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Chronological ageing and ovarian reserve in MS: insights from anti-Müllerian hormone and disability progression.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Durable fluoropolymer drug-eluting stent versus bare-metal stent for the prevention of intracranial in-stent restenosis.

Journal of neurology, neurosurgery, and psychiatry·2026
See all related articles

Diffuse axonal injury (DAI) occurs in head trauma, with a spectrum of severity. Some patients with DAI can recover enough to speak after their initial injury and coma.

Area of Science:

  • Neuroscience
  • Pathology
  • Trauma Surgery

Background:

  • Diffuse axonal injury (DAI) is a common consequence of severe head trauma.
  • Understanding the spectrum and clinical impact of DAI is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the incidence and spectrum of diffuse axonal injury in head trauma patients.
  • To correlate macroscopic "marker" lesions with the severity of DAI.

Main Methods:

  • Retrospective analysis of 80 consecutive head trauma cases.
  • Clinical assessment by the Royal Adelaide Hospital Neurosurgery Unit.
  • Detailed microscopic examination for DAI diagnosis.

Main Results:

  • Diffuse axonal injury (DAI) was identified in 34 of 80 cases.

Related Experiment Videos

  • Approximately one-third of DAI patients showed recovery of speech between coma and death.
  • Macroscopic marker lesions were present in only 15/34 DAI cases, indicating the most severe DAI spectrum.

    • Conclusions:

    • DAI represents a spectrum of injury, not a uniform condition.
    • Clinical recovery, including speech, is possible in a subset of DAI patients.
    • Macroscopic lesions are indicative of severe DAI but not universally present.