Related Experiment Video
Updated: Mar 14, 2026
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
Outcomes and feasibility of nipple-sparing mastectomy for node-positive breast cancer Patients
Brittany L Murphy1, Tanya L Hoskin2, Judy C Boughey1
1Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Background:
While nipple-sparing mastectomy (NSM) is gaining acceptance for risk reduction and for treatment of early stage breast cancer, node-positive disease remains a relative contraindication. Our aim was to evaluate the use and outcomes of NSM in node-positive breast cancer patients.
Methods:
We identified 240 cancers in 226 patients (14 bilateral) scheduled for NSM and operated on between 1/2009 and 6/2014. We compared outcomes for 58 node-positive vs 182 node-negative patients.
Results:
Intraoperative conversion to skin-sparing mastectomy was similar for node-positive and node-negative patients, 10% and 7%, as was 1-year success of NSM, 84% and 90%, respectively. Five-year locoregional disease-free estimates were 82% (95% CI 68%-99%) for node-positive and 99% (95% CI 96%-100%) for node-negative patients, P = .004; however, there were no nipple-areolar recurrences among node-positive patients.
Conclusions:
With careful consideration of biologic and anatomic risk factors for recurrence, these data suggest that NSM is a reasonable option for selected node-positive breast cancer patients.
