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The role of miRNAs in cardiovascular disease risk factors

Joy N Jones Buie1, Andrew J Goodwin2, James A Cook3

  • 1Medical University of South Carolina, Department of Pathology and Laboratory Medicine, 173 Ashley Avenue, Suite CRI 605B, Charleston, United States.

Atherosclerosis
|October 4, 2016
PubMed

Insights

MicroRNAs (miRNAs) show altered expression in cardiovascular diseases. This review explores their role in risk factors like hypertension and diabetes, highlighting their potential as biomarkers and therapeutic targets.

Area of Science:

  • Biochemistry
  • Genetics
  • Cardiology

Background:

  • Coronary artery disease (CAD) and atherosclerosis are multifactorial diseases influenced by genetics and environment.
  • MicroRNAs (miRNAs) are differentially expressed in CAD and atherosclerosis patients.
  • The link between miRNA alterations and cardiovascular disease risk factors (hyperlipidemia, hypertension, obesity, diabetes, inactivity, smoking) is not fully understood.

Purpose of the Study:

  • To review the literature on miRNAs in relation to cardiovascular disease risk factors.
  • To explore the role of miRNAs as potential biomarkers and contributors to the pathophysiology of these risk factors.
  • To summarize findings from human and animal studies on miRNA level alterations.

Main Methods:

  • Systematic literature review of published studies.
  • Analysis of human and animal research on miRNA expression.
  • Examination of proposed mechanisms for miRNA effects.

Main Results:

  • miRNA expression is altered in association with major cardiovascular risk factors.
  • miRNAs may act as beneficial or detrimental factors in disease development.
  • Evidence suggests miRNAs can serve as biomarkers for cardiovascular risk.

Conclusions:

  • miRNAs are implicated in the pathophysiology of cardiovascular risk factors.
  • Further research is needed to elucidate the precise roles of miRNAs.
  • Collaborative studies are essential to advance understanding and therapeutic strategies for cardiovascular diseases.

Keywords:
Cardiovascular diseaseCoronary artery diseaseReviewRisk factorsmiRNA

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