Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structural Protein Function01:56

Structural Protein Function

30.4K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.4K
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

3.6K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
3.6K
Extracellular Matrix01:26

Extracellular Matrix

6.3K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
6.3K
Fibrous Proteins00:55

Fibrous Proteins

5.0K
Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
5.0K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
The Extracellular Matrix01:29

The Extracellular Matrix

13.0K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
13.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ensemble Machine Learning- and Deep Learning-Driven Identification and Validation of Sennidin B as a Novel Dipeptidyl Peptidase-4 Inhibitor.

International journal of molecular sciences·2026
Same author

Assessing future invasion risk by Solanum viarum Dunal in Northwestern Himalaya to inform early detection and management.

Scientific reports·2026
Same author

Integrated analysis of miRNA and transcription factor gene expression profiles associated with anti-tuberculosis treatment responses.

BMC infectious diseases·2026
Same author

Therapeutic potential of Amentoflavone against myostatin for skeletal muscle atrophy treatment: An in silico, in vitro, and in vivo study.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Top-Down Mass Spectrometry and Its Current Applications in Biomarker Discovery in Aging and Age-Related Diseases.

International journal of molecular sciences·2026
Same author

Therapeutic Evaluation of the Suprachoroidal Space for Stem Cell Delivery in Retinal Degeneration.

Stem cells international·2026

Related Experiment Video

Updated: Mar 14, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

5.2K

Fibromodulin: A regulatory molecule maintaining cellular architecture for normal cellular function.

Arif Tasleem Jan1, Eun Ju Lee1, Inho Choi1

  • 1Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, Republic of Korea.

The International Journal of Biochemistry & Cell Biology
|October 4, 2016
PubMed
Summary

Fibromodulin (FMOD), a proteoglycan, regulates tissue integrity through interactions with lysyl oxidase (LOX). Its roles extend beyond the extracellular matrix to cellular processes like muscle development and angiogenesis.

Keywords:
Cellular structureExtracellular matrixFibromodulinProteoglycans

More Related Videos

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay
11:38

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay

Published on: September 14, 2021

3.9K
Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
06:56

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

Published on: September 28, 2020

1.4K

Related Experiment Videos

Last Updated: Mar 14, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

5.2K
Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay
11:38

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay

Published on: September 14, 2021

3.9K
Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
06:56

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

Published on: September 28, 2020

1.4K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Tissue Engineering

Background:

  • Fibromodulin (FMOD) is a small leucine-rich proteoglycan involved in biological and pathophysiological processes.
  • FMOD interacts with lysyl oxidase (LOX) to regulate extracellular matrix composition and cellular turnover.
  • Recent research highlights FMOD's roles in muscle development, cell reprogramming, and angiogenesis, extending beyond matrix maintenance.

Purpose of the Study:

  • To elucidate the multifaceted roles of Fibromodulin (FMOD) in cellular behavior and tissue properties.
  • To understand FMOD's impact on tissue integrity for potential therapeutic and modeling applications.

Main Methods:

  • Literature review and synthesis of existing research on FMOD functions.
  • Analysis of FMOD's interactions with key proteins like lysyl oxidase (LOX).
  • Examination of FMOD's involvement in diverse cellular processes including matrix assembly, muscle development, and angiogenesis.

Main Results:

  • FMOD's interaction with LOX is crucial for regulating extracellular matrix.
  • FMOD influences cellular processes beyond matrix assembly, including development, reprogramming, and angiogenesis.
  • FMOD is central to cellular behavior and ultimately determines tissue properties.

Conclusions:

  • Fibromodulin (FMOD) plays a critical role in maintaining tissue integrity.
  • Understanding FMOD's broad biological functions is essential for its application in tissue modeling and treating disorders.