Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mortality patterns among workers exposed to acrylamide.

J J Collins1, G M Swaen, G M Marsh

  • 1American Cyanamid Company, One Cyanamid Plaza, Wayne, NJ 07470.

Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A constrained maximum likelihood approach to evaluate the impact of dose metric on cancer risk assessment: application to β-chloroprene.

Regulatory toxicology and pharmacology : RTP·2014
Same author

Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies.

Critical reviews in toxicology·2007
Same author

Indoor environment and respiratory symptoms in children living in the Dutch-German borderland.

International journal of hygiene and environmental health·2005
Same author

Cancer dose--response assessment for acrylonitrile based upon rodent brain tumor incidence: use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity.

Regulatory toxicology and pharmacology : RTP·2005
Same author

The influence of occupational exposure to pesticides, polycyclic aromatic hydrocarbons, diesel exhaust, metal dust, metal fumes, and mineral oil on prostate cancer: a prospective cohort study.

Occupational and environmental medicine·2005
Same author

Associations between infections and fatigue in a Dutch working population: results of the Maastricht Cohort Study on Fatigue at Work.

European journal of epidemiology·2003

This study examined mortality risks for 8,854 men, including 2,293 exposed to acrylamide. Researchers found no significant increase in overall or cancer-specific mortality, suggesting acrylamide is not a human carcinogen.

Area of Science:

  • Occupational health
  • Toxicology
  • Epidemiology

Background:

  • Acrylamide is a chemical used in various industrial processes.
  • Concerns exist regarding its potential carcinogenic effects in humans.
  • Previous studies have yielded inconclusive evidence on acrylamide's carcinogenicity.

Purpose of the Study:

  • To investigate the long-term mortality risks associated with occupational acrylamide exposure.
  • To determine if acrylamide exposure increases the risk of all-cause or cause-specific mortality, particularly cancer.

Main Methods:

  • A cohort study design involving 8,854 men from four plant populations in the United States and The Netherlands.
  • Mortality data was collected between 1925 and 1983 for 2,293 men with documented acrylamide exposure.

Related Experiment Videos

  • Statistical analyses were performed to assess mortality risks based on exposure levels and causes of death.

    • Main Results:

    • No statistically significant excess of all-cause mortality was observed in the acrylamide-exposed group compared to the unexposed.
    • Analysis of cause-specific mortality, including various cancer sites, did not reveal a significant increase in risk among workers exposed to acrylamide.
    • No discernible trend of increased mortality risk was associated with higher levels of acrylamide exposure.

    Conclusions:

    • The findings do not support the hypothesis that acrylamide is a human carcinogen.
    • Occupational exposure to acrylamide in this cohort was not linked to increased mortality.
    • Further research may be warranted, but current evidence suggests a lack of carcinogenic potential in humans.