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As people age, their ability to predict movement consequences declines, reducing sensorimotor attenuation. This age-related decline in motor control is linked to changes in the pre-supplementary motor area (pre-SMA).

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Area of Science:

  • Neuroscience
  • Gerontology
  • Motor Control

Background:

  • Voluntary movement control significantly changes with age.
  • Sensorimotor attenuation, a reduction in perceived sensation intensity from self-generated actions, is crucial for motor control.
  • This attenuation relies on integrating sensory input with internal predictive models.

Purpose of the Study:

  • To investigate how sensorimotor attenuation changes with age.
  • To explore the neural underpinnings of age-related alterations in sensorimotor attenuation.
  • To determine the relationship between sensorimotor attenuation, sensory sensitivity, and brain structure/function.

Main Methods:

  • A population-based cohort (n=325, ages 18-88) was studied.
  • Sensorimotor attenuation was measured.
  • Magnetic resonance imaging (MRI) assessed the structure and functional connectivity of the pre-supplementary motor area (pre-SMA).

Main Results:

  • Sensorimotor attenuation was present in 98% of adults.
  • Attenuation increased with age, correlating with reduced sensory sensitivity.
  • Age-related changes in pre-SMA structure and connectivity were observed.

Conclusions:

  • Ageing alters the balance between sensory processing and predictive motor models.
  • The pre-supplementary motor area (pre-SMA) and its frontostriatal connections mediate this age-related shift.
  • This neural shift may underlie observed age-related motor and cognitive changes.