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Cannabisol, a novel Δ9-THC dimer possessing a unique methylene bridge, isolated from Cannabis sativa
Fazila Zulfiqar1, Samir A Ross2, Desmond Slade1
1National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University MS 38677, USA.
Tetrahedron Letters
|October 4, 2016
Abstract:
Cannabisol (1), a unique dimer of Δ9-tetrahydrocannabinol (Δ9-THC) with a methylene bridge, was isolated from Cannabis sativa. This is the first example of a C-bridged dimeric cannabinoid. The structure of 1 was unambiguously deduced by HRESIMS, GCMS, and NMR spectroscopy. A plausible biogenesis of 1 is described.