Related Experiment Video

Updated: Mar 14, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
06:50

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

3.3K

Characterization of Obesity in the Prader-Labhart-Willi Syndrome: Fatness Patterning

F John Meaney1, Merlin G Butler2

  • 1Hypertension Research Center, Charles R. Drew University of Medicine and Science.

Medical Anthropology Quarterly
|October 4, 2016
PubMed

Insights

Prader-Labhart-Willi Syndrome (PLWS) patients exhibit significantly higher fatness scores compared to the general population. Anthropometric measurements reveal males with PLWS have triple the fatness scores, while females have double.

Area of Science:

  • Clinical Genetics
  • Human Physiology
  • Pediatric Endocrinology

Background:

  • Prader-Labhart-Willi Syndrome (PLWS) is a complex genetic disorder.
  • Obesity is a major clinical feature of PLWS, impacting diagnosis and prognosis.
  • Understanding fat distribution is crucial for managing PLWS patients.

Purpose of the Study:

  • To improve diagnosis and prognosis of PLWS.
  • To quantitatively assess fatness at different body sites in PLWS individuals using anthropometry.
  • To compare anthropometric data of PLWS patients with normative data.

Main Methods:

  • Multidisciplinary study including cytogenetic, clinical, and anthropometric assessments.
  • Collected 26 anthropometric measurements, including 7 skinfold thicknesses.
  • Calculated Z-scores for skinfold measurements and compared with normative data, stratified by age, sex, and chromosome type.

Main Results:

  • PLWS males showed three times the fatness scores compared to age-matched controls.
  • PLWS females averaged twice the fatness scores of normal females.
  • Significant quantitative differences in fatness were observed at various body sites.

Conclusions:

  • Anthropometry is a valuable tool in the clinical genetics evaluation of PLWS.
  • This study provides a comprehensive approach to understanding the heterogeneity of obesity in PLWS.
  • Findings support targeted interventions for obesity management in PLWS.

More Related Videos

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas03:07

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

456
Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography13:09

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

16.7K

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
343
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
325
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.8K
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
8.3K
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
1.8K