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Updated: Mar 14, 2026

06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
988
Synchronous trifocal colorectal cancer
Petros Charalampoudis1, Georgios C Sotiropoulos1, Stylianos Kykalos1
1Second Department of Propedeutic Surgery, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Summary
Synchronous colorectal cancers (SCRCs) are increasingly diagnosed. This case highlights a rare instance of three distinct colorectal cancers found in one patient, emphasizing the importance of thorough colonoscopy evaluations.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Oncology
Background:
- Synchronous colorectal cancers (SCRCs) are defined as two or more distinct primary neoplasms in the colorectum.
- While SCRCs are increasingly diagnosed due to advancements in imaging and endoscopic techniques, the occurrence of three or more synchronous tumors is exceptionally rare.
Observation:
- A 76-year-old male presented with two identified colorectal adenocarcinomas during a total colonoscopy.
- Initial staging with abdominal ultrasonography and thoracoabdominal computed tomography did not reveal metastatic disease.
Findings:
- The patient underwent a left hemicolectomy for the identified tumors.
- Postoperative pathological examination confirmed the presence of three distinct, moderately differentiated colorectal adenocarcinomas.
Implications:
- This case underscores the potential for multiple synchronous colorectal cancers, even when initial assessments suggest fewer.
- It highlights the critical role of comprehensive pathological evaluation in accurately determining the number and characteristics of colorectal neoplasms.
- Increased vigilance and thoroughness in diagnosis and surgical planning are essential for managing complex SCRC cases.

