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Managing eosinophilic esophagitis: challenges and solutions.

Nisha A Shah1, Dustin M Albert1, Noah M Hall1

  • 1Department of Medicine, Gastroenterology Service, Walter Reed National Military Medical Center, Bethesda, MD, USA.

Clinical and Experimental Gastroenterology
|October 4, 2016
PubMed
Summary

Eosinophilic esophagitis (EoE) is a chronic immune condition. Current therapies manage symptoms, but new validated measures and maintenance strategies are needed for better treatment endpoints and disease control.

Keywords:
allergycorticosteroidsdietary treatmentdilationdysphagiaeosinophiliaeosinophilic esophagitisesophagitis

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Area of Science:

  • Immunology
  • Gastroenterology

Background:

  • Eosinophilic esophagitis (EoE) is a chronic, progressive immune condition causing esophageal dysfunction and eosinophil buildup.
  • Symptoms include dysphagia and food impaction, impacting quality of life.

Approach:

  • Current therapies involve anti-eosinophilic medications and diets to manage EoE symptoms and progression.
  • Assessing treatment response is challenging due to undefined clinical, histologic, and endoscopic endpoints.

Key Points:

  • Validated measures are emerging to standardize EoE treatment endpoints.
  • Maintenance therapy shows promise in reducing disease progression.
  • Esophageal dilation is effective for fibrostenosis symptoms.

Conclusions:

  • Optimal treatment dosages, delivery, and duration require further investigation.
  • Novel therapies targeting inflammatory mediators are under development for refractory EoE cases.