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Characteristics of mucoid Streptococcus pyogenes isolated from two patients with pneumonia in a local community

Nobuaki Mori1, Sakiko Hosoo2, Yoshitaka Oyamada2

  • 1Department of General Internal Medicine, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan; Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane Minato-ku, Tokyo 108-8641, Japan.

Idcases
|October 4, 2016
PubMed

Insights

Mucoid Streptococcus pyogenes (Group A Streptococcus) pneumonia, though rare, can spread within communities. Similar GAS strains were found in two unrelated patients whose families had contact through a kindergarten epidemic.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Group A Streptococcus (GAS) infections can lead to severe, life-threatening conditions.
  • GAS pneumonia is an uncommon manifestation, particularly within local communities.

Purpose of the Study:

  • To characterize mucoid GAS isolates from two unrelated pneumonia patients in a community.
  • To investigate potential epidemiological links between the cases, given a concurrent GAS pharyngitis outbreak in a local kindergarten.

Main Methods:

  • Phenotypic and genotypic analyses were performed on GAS isolates.
  • Methods included API-20 Strep system, 16S rRNA sequencing, emm typing, sequence typing, sic allele analysis, antimicrobial susceptibility testing, random amplified polymorphic DNA (RAPD) analysis, and pulse-field gel electrophoresis (PFGE).

Main Results:

  • Phenotypic and genotypic analyses showed significant similarity between the GAS isolates from both patients.
  • Despite no direct contact between patients, their families were linked through a kindergarten experiencing a GAS pharyngitis epidemic.

Conclusions:

  • Mucoid GAS infections in adults warrant investigation into household contacts and local community outbreaks, especially in settings like kindergartens.
  • The findings highlight the importance of considering community transmission dynamics in GAS pneumonia cases.
Keywords:
Local communityMucoid strainPneumoniaStreptococcus pyogenes

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