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A practical overview of the treatment 
of chronic hepatitis C virus infection

Anthony Khoo, Edmund Tse

    Australian Family Physician
    |October 4, 2016
    PubMed

    Insights

    All patients with chronic hepatitis C (HCV) infection should consider treatment with direct-acting antiviral (DAA) medications. These well-tolerated, highly effective oral regimens offer a cure, with cure confirmed by undetectable viral load 12 weeks post-treatment.

    Area of Science:

    • Hepatology
    • Infectious Diseases
    • General Practice

    Background:

    • Chronic hepatitis C virus (HCV) infection presents significant global morbidity and mortality.
    • Effective community-based management strategies are crucial for improving patient outcomes.

    Purpose of the Study:

    • To provide general practitioners (GPs) with an overview of assessing and treating chronic HCV in a community setting.
    • To guide GPs on the principles of HCV management, including treatment indications and specialist referral criteria.

    Main Methods:

    • Review of current guidelines and evidence for HCV assessment and treatment.
    • Focus on direct-acting antiviral (DAA) therapies available on the Pharmaceutical Benefits Scheme (PBS).
    • Emphasis on pre-treatment evaluation, including assessment for cirrhosis, comorbidities, and drug-drug interactions.

    Main Results:

    • DAA regimens are well-tolerated, highly efficacious, and administered orally.
    • Treatment is recommended for all patients with chronic HCV infection.
    • Specialist referral is advised for patients with cirrhosis, significant comorbidities, or potential drug-drug interactions.

    Conclusions:

    • Successful HCV eradication is defined by undetectable HCV RNA viral load 12 weeks post-treatment.
    • HCV antibodies may remain positive lifelong, irrespective of viral clearance.
    • Community-based treatment with DAAs is a key strategy for managing chronic HCV infection.
    Abstract

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