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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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Dengue scenario: Chennai perspective-a six-year study (2009-2014).
P Padmapriya1,2, V Senthil Kumar2, R Senthil Raja2
1Bioproducts Lab, CSIR-Central Leather Research Institute, Adyar, Chennai, 600 032, India.
Archives of Virology
|October 4, 2016
Summary
Dengue fever is endemic in Chennai, India, with nearly 20% of suspected cases confirmed over six years. Pediatric cases showed higher infection rates and severe dengue manifestations, highlighting the need for vigilant monitoring.
Area of Science:
- Medical Virology
- Epidemiology
- Public Health
Background:
- Dengue fever presents a significant global public health challenge with rising incidence and wider geographic spread.
- The disease is transitioning from epidemic to endemic patterns in tropical and subtropical regions.
Purpose of the Study:
- To analyze dengue seroprevalence and clinical manifestations over a six-year period (2009-2014) in Chennai, India.
- To investigate the occurrence of Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS), particularly in pediatric populations.
Main Methods:
- Analysis of 10,099 serum samples from suspected dengue cases using IgM ELISA (NIV Capture) and IgG Panbio ELISA.
- Categorization of samples into pediatric (6,798) and adult (3,301) groups for comparative analysis.
Main Results:
- 1,927 out of 10,099 (19.08%) suspected cases were confirmed as dengue.
- Confirmed dengue cases were higher in pediatric (1,752/6,798, 25.7%) compared to adult (175/3,301, 5.3%) populations.
- Dengue Hemorrhagic Fever and Dengue Shock Syndrome were notably observed in the pediatric group.
Conclusions:
- Dengue is highly endemic in Chennai, with a significant burden on the pediatric population.
- Monitoring both IgM and IgG antibodies is crucial for understanding infection dynamics, disease spectrum, and circulating serotypes.
- These findings aid in early epidemic prediction and managing severe dengue manifestations like DHF and DSS.
