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Interleukin-35: a Potential Therapeutic Agent for Autoimmune Diseases
Shi-Yang Guan1,2, Rui-Xue Leng1,2, Muhammad Imran Khan1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China.
Inflammation
|October 4, 2016
Summary
Interleukin-35 (IL-35), a cytokine in the IL-12 family, is involved in autoimmune diseases like lupus and rheumatoid arthritis. Understanding IL-35's role may lead to new treatments for these conditions.
Area of Science:
- Immunology
- Molecular Biology
- Pathogenesis of Autoimmune Diseases
Background:
- Autoimmune diseases involve a loss of self-tolerance.
- Cytokine-mediated immunity is crucial in autoimmune disease development.
- Interleukin-35 (IL-35) is a recently identified cytokine implicated in various autoimmune conditions.
Purpose of the Study:
- To review the biological characteristics of IL-35.
- To summarize current research on IL-35's role in autoimmune disease pathogenesis.
- To explore the therapeutic potential of targeting IL-35.
Main Methods:
- Literature review of recent studies on IL-35.
- Analysis of IL-35's involvement in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc).
- Discussion of IL-35's biological functions and impact on immune responses.
Main Results:
- IL-35 plays a significant role in the pathogenesis of multiple autoimmune diseases.
- Evidence links IL-35 to conditions including SLE, RA, and SSc.
- IL-35 exhibits specific biological features relevant to immune regulation.
Conclusions:
- IL-35 is a key player in the development of autoimmune diseases.
- Further research into IL-35 mechanisms could reveal novel therapeutic strategies.
- Targeting IL-35 may offer a promising avenue for treating autoimmune disorders.
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