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Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma

Kaveh Ardalan1, Christina K Zigler2, Kathryn S Torok2

  • 1Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Arthritis Care & Research
|October 4, 2016
PubMed

Insights

Extracutaneous manifestations and female sex predict lower quality of life (QoL) in children with localized scleroderma. However, QoL impact decreases over time since the initial visit.

Area of Science:

  • Pediatric Dermatology
  • Rheumatology
  • Quality of Life Research

Background:

  • Localized scleroderma significantly impacts children's quality of life (QoL).
  • Predictors of this QoL impact in juvenile localized scleroderma (jLS) are not well understood.
  • Identifying these predictors is crucial for targeted interventions.

Purpose of the Study:

  • To identify predictors of QoL impact in patients with juvenile localized scleroderma.
  • To analyze the relationship between disease characteristics and QoL outcomes.
  • To inform clinical management and psychosocial support strategies.

Main Methods:

  • Analysis of longitudinal data from a single-center cohort of jLS patients.
  • Utilized hierarchical generalized linear modeling (HGLM) to account for nested data structures.
  • Evaluated both time-variant and time-invariant predictors of QoL impact.

Main Results:

  • The presence of extracutaneous manifestations (ECMs) and female sex were significant predictors of negative QoL impact (Children's Dermatology Life Quality Index score >1).
  • Increased time since the initial patient visit was associated with a decreased likelihood of reporting negative QoL impact.
  • Extracutaneous manifestations and sex were more predictive of QoL impact than cutaneous disease features.

Conclusions:

  • Extracutaneous manifestations and sex are key factors influencing QoL in jLS.
  • The protective effect of time since initial visit warrants further investigation.
  • Understanding these predictors can help identify at-risk patients and tailor supportive care.
Abstract

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