Multi-targeting Andrographolide and its Natural Analogs as Potential Therapeutic Agents
V Kishore, Nagendra Sastry Yarla1, Anupam Bishayee
1Department of Biochemistry, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India.
Current Topics in Medicinal Chemistry
|October 5, 2016
Summary
Andrographis paniculata, containing andrographolide, offers therapeutic benefits including anti-inflammatory and hepatoprotective effects. Further research explores its diverse pharmacological activities and mechanisms for disease prevention.
Area of Science:
- Phytochemistry
- Pharmacology
- Traditional Medicine
Background:
- Andrographis paniculata (A. paniculata) is a medicinal herb utilized in traditional Indian and Chinese medicine.
- Its therapeutic properties are primarily attributed to the compound andrographolide, a diterpene lactone.
- Andrographolide and its analogs exhibit a wide range of biological activities.
Purpose of the Study:
- To provide a comprehensive overview of the therapeutic and pharmacological activities of andrographolide and its derivatives.
- To highlight the potential of A. paniculata compounds in disease prevention.
- To exemplify the underlying mechanisms responsible for these biological actions.
Main Methods:
- Literature review of scientific studies on Andrographis paniculata and andrographolide.
- Analysis of reported biological activities and pharmacological effects.
- Examination of research investigating the mechanisms of action.
Main Results:
- Andrographolide and related terpenoids possess significant anti-inflammatory, anti-tumour, anti-hyperglycaemic, anti-fertility, antiviral, cardioprotective, and hepatoprotective properties.
- Structural similarities among these compounds correlate with diverse pharmacological activities.
- Ongoing research aims to elucidate the specific molecular pathways involved.
Conclusions:
- Andrographolide and its derivatives from A. paniculata represent a promising source for therapeutic agents.
- The diverse pharmacological profile supports their use in disease prevention and treatment.
- Further mechanistic studies are crucial for drug development and validation.
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