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Updated: Mar 14, 2026
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Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level
Published on: January 24, 2025
18F-FDG-PET Correlates of Impulse Control Disorder in a Diabetic Patient
Burak Yulug1, Lütfü Hanoglu, Ahmet Mithat Tavlı
1Istanbul-Medipol University, Department of Neurology, Istanbul,. Turkey.
Background:
Studies have already shown that hyperglycemia and insulin resistance are significantly associated with the impairment of cerebral glucose metabolism that may secondary lead to cognitive disturbances. In this study, we aimed to evaluate the neurometabolic correlates of diabetes in a patient with Intermittent explosive disorder (IED).
Methods:
We have investigated the cerebral glucose metabolism via 2-[18F]-fluoro-2- deoxy-D-glucose positron emission tomography (FDG-PET) in a diabetic patient with aggressive outbursts.
Results:
We have found significantly reduced glucose uptake in left temporoparietal region, pontin area, and left nucleus lentiformis.
Discussion:
Our present results indicate decreased cerebral glucose metabolism in specific cerebral cortical and subcortical areas. The main limitation of this report is that, this is a single case study and that these findings need to be replicated in well- conducted randomized controlled studies by using additional neuroquantitative methods.
