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Updated: Mar 14, 2026

Dual Somatic Recordings from Gonadotropin-Releasing Hormone GnRH Neurons Identified by Green Fluorescent Protein GFP in Hypothalamic Slices
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Gonadotrope Tumors.

S L Asa1, S Ezzat2

  • 1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada.

Progress in Molecular Biology and Translational Science
|October 5, 2016
PubMed
Summary
This summary is machine-generated.

Gonadotrope tumors are common pituitary tumors originating from adenohypophysis gonadotropes. Their cause is unknown, and effective non-surgical treatments are unavailable, necessitating further research into these tumors.

Keywords:
adenomabiochemistryepidemiologygonadotropeimmunohistochemistrymorphologypathogenesistumor

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Area of Science:

  • Endocrinology
  • Oncology
  • Cell Biology

Background:

  • Gonadotrope tumors are frequent pituitary neoplasms.
  • They originate from the gonadotrope cells of the adenohypophysis.
  • Gonadotrope hyperplasia is rare, typically linked to premature gonadal failure.

Purpose of the Study:

  • To review the pituitary gonadotrope from morphologic and functional viewpoints.
  • To elucidate the cell of origin for common pituitary tumors.
  • To provide insights into the pathogenesis of gonadotrope tumors.

Main Methods:

  • Literature review of pituitary gonadotrope morphology and function.
  • Analysis of existing data on gonadotrope tumors and hyperplasia.
  • Synthesis of information regarding the cell of origin for pituitary neoplasms.

Main Results:

  • Gonadotrope tumors are a common type of pituitary tumor.
  • The pathogenesis of these tumors remains largely unknown.
  • Current nonsurgical therapeutic options are limited.

Conclusions:

  • Understanding the pituitary gonadotrope is crucial for deciphering tumor origins.
  • Further research is needed to uncover the pathogenesis of gonadotrope tumors.
  • Development of effective nonsurgical therapies is a significant unmet need.