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Updated: Mar 14, 2026
Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
Calcific aortic stenosis and its correlation with a novel inflammatory marker, the lymphocyte/monocyte ratio
Tolga Han Efe1, Kadriye Gayretli Yayla1, Cagri Yayla2
1Department of Cardiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Insights
The lymphocyte/monocyte ratio inversely correlates with calcific aortic stenosis severity. Lower ratios indicate more severe aortic stenosis, suggesting its potential as an inflammatory marker in this cardiovascular disease.
Area of Science:
- Cardiology
- Inflammation Research
- Hematology
Background:
- Calcific aortic valve disease is a progressive condition leading to valve replacement in elderly patients.
- The lymphocyte/monocyte ratio (LMR) is an emerging inflammatory marker in cardiovascular disease.
- Understanding LMR's role in aortic stenosis is crucial for disease management.
Purpose of the Study:
- To investigate the correlation between the severity of calcific aortic stenosis and the LMR.
- To determine if LMR can serve as a predictive marker for aortic stenosis progression.
Main Methods:
- Retrospective study of 178 patients with calcific aortic stenosis and 139 controls.
- Patients categorized into mild-to-moderate and severe aortic stenosis groups.
- Analysis of LMR in relation to stenosis severity and demographic data.
Main Results:
- A statistically significant inverse correlation was found between aortic stenosis severity and LMR (r=-0.232, p=0.002).
- LMR decreased progressively with increasing aortic stenosis severity across all patient groups.
- Multivariate analysis confirmed LMR as an independent predictor of calcific aortic stenosis severity (p=0.003).
Conclusions:
- A significant inverse relationship exists between calcific aortic stenosis severity and LMR.
- LMR is significantly associated with the progression of aortic valve stenosis.
- LMR may serve as a valuable inflammatory biomarker in calcific aortic valve disease.
Introduction:
Calcific aortic valve disease, a chronic progressive disorder, is the leading cause of valve replacement among elderly patients. The lymphocyte/monocyte ratio has been recently put forward as an inflammatory marker of relevance in several cancers as well as in cardiovascular disease. This study aims to assess the correlation between severity of calcific aortic stenosis and the lymphocyte/monocyte ratio.
Methods:
The study retrospectively included 178 patients with a diagnosis of calcific aortic stenosis and 139 age- and gender-matched controls. The patients were divided into two groups according to the severity of aortic stenosis: mild-to-moderate and severe.
Results:
An inverse correlation was discerned between the severity of the aortic stenosis process (mean gradient) and the lymphocyte/monocyte ratio (r=-0.232, p=0.002). The lymphocyte/monocyte ratio was observed to decrease as the severity of aortic stenosis increased (p<0.001) in the group with severe aortic stenosis compared with the mild-to-moderate aortic stenosis and control groups (p<0.001, p=0.005 respectively), and in the group with mild-to-moderate aortic stenosis compared with the control group (p=0.003). Multivariate regression analysis revealed that the lymphocyte/monocyte ratio was independently related to the severity of calcific aortic stenosis (p=0.003).
Conclusion:
The present study demonstrated the existence of a statistically significant inverse relationship between severity of calcific aortic stenosis and the lymphocyte/monocyte ratio. The study also revealed that the lymphocyte/monocyte ratio was significantly related to the severity of the aortic valve stenosis process.
