Related Experiment Video

Updated: Mar 14, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

479

DNA damage response regulation by microRNAs as a therapeutic target in cancer

Maryam Majidinia1, Bahman Yousefi2

  • 1Department of Clinical Biochemistry, Faculty of Medicine, Urmia University Medical Sciences, Urmia, Iran; Molecular Targeting Therapy Research Group, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

DNA Repair
|October 5, 2016
PubMed

Insights

Cancer cells’ DNA repair defects drive cancer. DNA damage response (DDR) pathways interact with microRNAs (miRNAs), offering new therapeutic targets for cancer treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Genomic instability from unrepaired DNA damage is a hallmark of cancer.
  • DNA damage response (DDR) pathways are crucial for maintaining genomic stability.
  • MicroRNAs (miRNAs) are key regulators of gene expression, increasingly implicated in cancer.

Purpose of the Study:

  • To review the intricate relationship between DDR pathways and miRNAs.
  • To explore how DDR influences miRNA expression and function.
  • To highlight the therapeutic potential of targeting miRNA-DDR interactions in cancer treatment.

Main Methods:

  • Literature review of recent studies on DDR and miRNA interactions.
  • Analysis of molecular mechanisms governing DDR-miRNA crosstalk.
  • Discussion of therapeutic strategies targeting miRNAs in DNA repair pathways.

Main Results:

  • DDR pathways modulate miRNA expression and stability.
  • miRNAs directly and indirectly regulate key proteins within DDR pathways.
  • Dysregulation of DDR-miRNA interactions contributes to cancer development and progression.

Conclusions:

  • Understanding DDR-miRNA interplay is vital for cancer research.
  • Targeting specific miRNAs involved in DNA repair presents a promising avenue for novel anticancer therapies.
  • Further research into miRNA-mediated regulation of DDR could lead to improved cancer treatments.
Keywords:
CancerChemotherapyDNA damage responseDNA repairmicroRNA

More Related Videos

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

9.0K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

8.1K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.5K
MicroRNAs01:22

MicroRNAs

12.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.6K
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
10.3K