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09:29
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
31.0K
Antivirals against animal viruses
T G Villa1, L Feijoo-Siota1, J L R Rama1
1Department of Microbiology, Biotechnology Unit, Faculty of Pharmacy, University of Santiago de Compostela 15706, Spain.
Biochemical Pharmacology
|October 5, 2016
Summary
This review explores natural and synthetic antivirals, highlighting natural compounds for future drug development. It emphasizes the need for new antiviral strategies due to viral resistance.
Area of Science:
- Pharmacology
- Virology
- Natural Product Chemistry
Background:
- Antivirals, used since the 1960s, combat viral infections by interfering with viral development.
- These compounds originate from natural sources (animals, plants, microbes) or chemical synthesis.
- Viruses' ability to develop resistance necessitates continuous research for novel antiviral agents.
Purpose of the Study:
- To review natural and synthetic antiviral compounds in chronological order.
- To emphasize natural compounds as a basis for future antiviral treatments.
- To explore diverse antiviral mechanisms and their impact on viral replication and host immunity.
Main Methods:
- Literature review of natural and synthetic antivirals.
- Chronological analysis of antiviral discoveries and development.
- Emphasis on natural product-derived antivirals.
Main Results:
- Overview of various antiviral sources and synthesis methods.
- Description of diverse mechanisms of action, including immune enhancement and enzyme inhibition.
- Identification of challenges such as host toxicity and viral resistance.
Conclusions:
- Natural compounds offer a promising foundation for developing novel antiviral therapies.
- Understanding antiviral mechanisms is crucial for effective treatment design.
- Continued research is essential to overcome viral resistance and improve antiviral efficacy.
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